Trazodone Side Effects | Used For Sleep, Interaction with Alcohol

Drug Class and Mechanism:

An oral antidepressant, this drug (Trazodone) has an effect on the chemical messengers (also known as neurotransmitters) inside the brain which the nerves use in order to correspond with (stimulate) one another. The key neurotransmitters are dopamine, acetylcholine, serotonin and norepinephrine. Many specialists believe that a discrepancy among the dissimilar neurotransmitters is what causes depression in people. Even though the precise mechanisms of the actions of Trazodone are unidentified, it probably develops signs of depression by reducing the serotonin uptake by the nerves within the brain. The result is that more serotonin is created to fuel other nerves. This drug may also raise directly the serotonin actions. Trazodone chemically is not linked to the SSRIs (selective serotonin reuptake inhibitors), the TCAs (tricyclic antidepressants) or the MAOIs (monoamine oxidase inhibitors). It’s chemically associated with nefazodone (Serzone) in addition to sharing its actions. It was in the year 1982 that the FDA approved Trazodone.


Prescribed For:

Trazodone is mainly made use of for treating depression. It’s sometimes approved in the form of a sedative, and it’s also used in grouping with additional drugs for treating agoraphobia, panic attacks, violent behavior, and cocaine abandonment.


Drug Interactions:

Every antidepressant that increases the concentration of serotonin within the brain, which includes Trazodone, must not be used with any MAO-inhibitor. Medicines within the MAO-inhibitor category consist of phenelzine (Nardil), isocarboxazid (Marplan), procarbazine (Matulane) and tranylcypromine (Parnate). Such permutations might lead to perplexity, lofty blood pressure and shivering. The same kind of interactions might come about when Trazodone is made use of along with selegiline (Eldepryl). In case a patient moves from using Trazodone to using an MAO inhibitor, as a minimum 1 week must be allowed after discontinuing Trazodone before any MAO inhibitors are begun. After discontinuing any MAO inhibitor, at least two weeks must elapse ahead of starting Trazodone.

Carbamazepine (Tegretol) might reduce blood levels of Trazodone as a result of escalating its removal from the body. indinavir (Crixivan), ritonavir (Norvir), and Ketoconazole (Nizoral), slow down the breakdown of this drug leading to amplified blood levels of Trazodone in addition to possible side effects.

Enlarged blood concentrations of phenytoin (Dilantin) and digoxin have been accounted for in people using Trazodone because of a decline in metabolism (i.e. the break-down and removal) of these medicines by Trazodone.



There aren’t any adequate researches on Trazodone in the case of pregnant women. Research in animals has confirmed consequences on a developing fetus. This drug must only be taken for the period of pregnancy in case the health care practitioner feels that the benefits outweigh the potential dangers.


Nursing Mothers:

Trazodone is capable of being secreted in a nursing mother’s breast milk. Therefore, prudence must be used when prescribing this drug to women that are breastfeeding their infants.


Key Information In Relation To Trazodone:

Prior to using Trazodone, inform your health care practitioner in case you have any bipolar disorder (or manic depression), “Long QT syndrome,” or heart ailment or liver ailment or kidney ailment, any record of a drug misuse or suicidal feelings, or in case you have had a stroke or heart attack recently.

Consuming alcohol might raise certain Trazodone side effects. Trazodone might impair your thoughts or responses. Be cautious if you’re driving or doing anything that calls for you to be attentive. Discontinue using Trazodone and get in touch with your health care practitioner immediately in case you have a painful penis erection that lasts for 6 hours or even longer. Such a situation is a health emergency and can lead to grave conditions that should be treated with a surgical procedure.


Prior to Using Trazodone:

Don’t use this drug if you’re sensitive to Trazodone. Don’t use Trazodone in case you have used an MAOI for instance isocarboxazid (Marplan), furazolidone (Furoxone), tranylcypromine (Parnate), rasagiline (Azilect), phenelzine (Nardil), or selegiline (Emsam , Eldepryl) in the past 14 days.

How to Use Trazodone?

Take as advised please …..

The Desyrel variety of Trazodone must be consumed following a snack or a meal. The Oleptro variety of Trazodone must be taken on a clear stomach before bedtime, unless your health care practitioner tells you otherwise. Your health care practitioner might ask you to split the extended-release pill and take just half of that. Don’t pound or chew up the extended-release tablets. Gulp down in one piece. Follow your health care practitioner’s directions. It might take close to 2 weeks by the time your symptoms get better. Keep using the drug as advised and inform your health care practitioner in case your symptoms don’t get better even 2 weeks after treatment. Don’t discontinue using Trazodone abruptly, or you might have horrid withdrawal symptoms. Inquire your health care practitioner on how to steer clear of withdrawal symptoms once you discontinue using Trazodone.


In Case Of an Overdose:

Get in touch with a help line immediately or request immediate emergency health attention. Symptoms of an overdose might consist of sleepiness, vomiting, a painful or lingering penis erection, hasty or throbbing heartbeat, seizures (black-outs or convulsion), or breathing that might slow down or stop. A Trazodone overdose can be lethal when it’s taken in the midst of alcohol, sedatives for example diazepam (Valium) or barbiturates for example phenobarbital.


What Are The Things To Avoid When Using Trazodone?

Don’t consume alcohol. Trazodone could raise the effect of alcohol, which might be hazardous. Steer clear of sitting up too quickly from a lying or sitting position, as this might make you feel giddy. Get up gradually and then steady yourself so you don’t fall. Consuming alcohol might raise certain Trazodone side effects.


Trazodone Side Effects for the User:

  • Distorted vision;
  • Constipation;
  • Decrease in ability or desire- sexually;
  • Diarrhea;
  • Lightheadedness;
  • Drowsiness;
  • Dryness in mouth;
  • Headaches;
  • Dizziness when standing or sitting up;
  • Muscle twinge or pains;
  • Nausea;
  • Anxiety;
  • Stuffy nose;
  • Stomach twinge;
  • Weariness.


It’s suggested that you demand medicinal attention without ado if any RELENTLESS Trazodone side effect occurs when consuming Trazodone:


Severe allergic reaction like:

  • Skin complaints;
  • Hives;
  • Itchiness;
  • Intricacy when breathing;
  • Rigidity in the torso;
  • Puffiness of the lips, mouth, face, or tongue);
  • Bloody, black or tarry stools;
  • Dark or bloody urine;
  • Chest soreness;
  • Decrease in dexterity;
  • Fainting;
  • Sore throat, fever, chills;
  • Delusions;
  • Jagged heartbeat;
  • Fresh or deteriorating agitation, anxiety, despair, panic attacks, violence, impulsiveness, bad temper, hostility, overstated feeling of comfort, restlessness, dilemma sleeping, or incapability to sit at rest;
  • Long-drawn-out, inappropriate, or sore erections;
  • Seizure;
  • Cruel or continual dizziness or weariness;
  • Shortness in breath;
  • Speech troubles;
  • Suicidal feelings or actions;
  • Puffiness of the ankles, hands, or feet;
  • Signs of stumpy blood sodium level (e.g., confusion, relentless headache, problem concentrating, recall problems, weakness, instability, sluggishness, trait changes);
  • Trembling;
  • Strange bruising or blood loss;
  • Unusual changes in weight;
  • Coffee ground looking vomit;
  • Paleness of the skin and eyes (jaundice).



What Are The Other Drugs That Will Have An Effect On Trazodone?

Inquire your health care practitioner ahead of taking any medication for inflammation, arthritis, fever or pain. This takes account of meloxicam (Mobic), ibuprofen (Motrin, Advil), naproxen (Naprosyn , Aleve, Naprelan, Treximet), indomethacin (Indocin), and aspirin, celecoxib (Celebrex) etc.

Using any of the mentioned medications along with Trazodone might cause easy blood loss or bruising.

Before taking Trazodone, notify your health care practitioner in case you frequently use additional medicines that might make you drowsy (for instance hypersensitivity or cold medication, narcotic soreness drug, tranquilizer, sleeping prescription, muscle relaxants, and prescription for convulsions or nervousness). They can fuel drowsiness which is caused by this drug.


Inform or notify your health care practioner if:


  • Digoxin (Lanoxicaps, Lanoxin);
  • Blood thinners for instance warfarin (Coumadin);
  • Antibiotics for example levofloxacin (Levaquin), pentamidine (Pentam, nebupent), clarithromycin (Biaxin), erythromycin (Ery-Tab, Erythrocin, E.E.S., eryped), and others;
  • Any further antidepressants, or a prescription to take care of psychiatric chaos;
  • Anti-malaria medication for example mefloquine (Lariam) or chloroquine (Arelan);
  • Antifungal medications for example itraconazole (Sporanox), ketoconazole (Ketozole, Nizoral, Extina, Xolegal), or voriconazole (Vfend);
  • Heart pace medication for example disopyramide (Norpace), amiodarone (Pacerone , Cordarone), quinidine (Quin-G), procainamide (Pronestyl),  and others;
  • Medicines for the heart or for blood pressure for example nifedipine (Procardia, Nifedical), verapamil (Covera, Calan, Verelan, Isoptin,, diltiazem (Cardizem, Cartia), and others;
  • Medicines to thwart or treat unsettled stomach and vomiting, for instance ondansetron (Zofran) or dolasetron (Anzemet);
  • HIV or AIDS medication for example ritonavir (Norvir), indinavir (Crixivan), fosamprenavir (Lexiva), and others;
  • Seizures medication for instance phenytoin (Dilantin) or carbamazepine (Tegretol, Carbatrol);
  • Narcotic prescription for example methadone (Methadose, Dolophine).