Pristiq Side Effects | Interactions with Alcohol and Drugs

Drug Class and Mechanism:

Desvenlafaxine is another name for Pristiq, which is an oral medicine that is made use of to treat depression. Pristiq belongs to a category of medication identified as SNRI (selective serotonin and norepinephrine reuptake inhibitors); a category that also includes duloxetine (Cymbalta) and Venlafaxine (Effexor). Desvenlafaxine have an effect on neurotransmitters, the chemical that the nerve inside the brain create and discharge so as to communicate with one another. A Neurotransmitter either travels across the gap between nerves and attaches to the receptor on the exterior of a nearby nerve or it attaches to a receptor on the exterior of the nerve that has produced it, so that it can be picked up by the same nerve and then freed again (a practice known as re-uptake).


Several experts are of the opinion that a disparity amongst neurotransmitters is what causes depression in people. Norepinephrine and Serotonin are the two neurotransmitters that are liberated by nerves within the brain. Pristiq works by averting the reuptake of epinephrine and serotonin by the nerves after they’ve been discharged. Since the uptake is an essential mechanism for getting rid of unrestricted neurotransmitters and ceasing their proceedings on adjoining nerves, the condensed uptake that is caused by Pristiq increases the results of norepinephrine and serotonin within the brain. Pristiq was approved in 2008 (February) by the FDA.


Vital Information Regarding Pristiq:

Pristiq is used as an antidepressant and hails from a cluster of medication identified as selective serotonin and norepinephrine reuptake inhibitors (SNRIs).

Pristiq is made use of to take care of major depressive disarrays since this drug influences the chemicals within the brain that might have turned unstable, thereby resulting in the person being depressed.

A person must not use Pristiq in case he/she is sensitive to venlafaxine (Effexor) or to Desvenlafaxine; or in case he/she is also taking an MAOI (monoamine oxidase inhibitors) for instance furazolidone (Furoxone), isocarboxazid (Marplan), rasagiline (Azilect), tranylcypromine (Parnate) phenelzine (Nardil), or selegiline (Emsam , Eldepryl).

Don’t use Pristiq in conjunction with Venlafaxine (Effexor).

A person might have feelings regarding suicide when he/she first starts using an antidepressant for instance Pristiq, particularly if he/she is lesser to 24 years in age. Your medical practitioner will want to examine you at standard visits for as a minimum the initial 12 weeks of this treatment.

Depression treatments are getting improved day by day and if you happen to suffer from depression, there are treatments now that you can begin doing without delay.

Get in touch with your health care practitioner at once in case you face any new or aggravated symptoms for instance: temper or behavior alterations, anxiety, fright attacks, difficulty sleeping, or in case you sense impulsiveness, irritability, agitation, hostility, aggressiveness, restlessness, hyper activeness (psychologically or bodily), further depressed, or have feelings regarding suicide or about harming yourself.

It might take more than a few weeks by the time your symptoms show any improvement. Keep using Pristiq as advised and inform your medical practitioner in case your symptoms don’t get better after some weeks of this treatment.


Prior to Using Pristiq:


Prior to using Pristiq, inform your medical provider in case you are sensitive to any medicines, or in case you have:


  • Bipolar disarray (or manic depression);
  • Liver ailment;
  • Kidney ailment;
  • Heart ailment, elevated blood pressure, elevated cholesterol, or a record of stroke or heart attack;
  • Glaucoma;
  • Convulsions or epilepsy;
  • A blood clotting or blood loss problem;
  • Stumpy level of sodium within your blood;
  • In case you were earlier using some other anti depressant and have now switched over to Pristiq.


A person might have feelings regarding suicide when he/she first starts using an antidepressant for instance Pristiq, particularly if he/she is lesser to 24 years in age. Your medical practitioner will want to examine you at standard visits for as a minimum the initial 12 weeks of this treatment. A patient’s family and his/her close friends must be alert to catch any alterations in the person’s symptoms or his/her mood swings.

Notify your medical practitioner in case you have aggravated symptoms regarding depression or suicidal feelings during the initial few weeks of this treatment or each time your prescribed amount is altered.


Pristiq might lead to problems in the case of a newborn child if his/her mother has used the prescription in the late stages of her pregnancy (at some stage in the 3rd trimester). Inform your medical practitioner in case you’re pregnant or planning a pregnancy for the period of treatment. Pristiq is capable of passing into a nursing mother’s breast milk and might cause harm to a nursing infant. Don’t take Pristiq without informing your health care practitioner if you’re breast-feeding your newborn. Don’t offer Pristiq to a person below 18 years in age without the guidance from a health care practitioner.


How to Use Pristiq:

Take this treatment just as it was suggested by the physician for you. Keep away from using the prescription in superior amounts or using it for longer than recommended by your health care provider. Your health care provider may occasionally alter your prescribed amount to make sure you’re receiving the greatest outcomes from Pristiq.

Pristiq can be taken with or without food. Try to take the medicine at the same time each day.

Don’t discontinue using Pristiq all of a sudden, as you might have disagreeable symptoms. Inquire your health care practitioner on how to evade these indications once you discontinue taking Pristiq.

It might take more than a few weeks by the time your symptoms show any improvement. Keep taking Pristiq as advised and inform your health care practitioner in case your symptoms don’t get better after some weeks of this treatment.

Don’t chew, pound, or split the extended-release pills. Swallow the drug in one piece. Splitting the tablets would cause a lot of the medication to be freed all at once.

A patient’s blood pressure must be examined time and again. Visit your health care practitioner on a regular basis.

Hoard Pristiq protected from high temperature and dampness and keep medication at room temperatures.


What Will Happen If You Fail To Spot And Leave Out A Dosage?

Consume the prescribed amount (that you have missed out on) the second you remember. (Make sure to take the drug together with food in case your health care practioner has instructed you to do so). Exclude the dosage that you have missed o if out on if it’s approximately time for the subsequent planned prescribed amount. Don’t use superfluous medication to make up for the dosage that you earlier missed out on.


What Will Happen If You Consume An Overdose Of Pristiq?

In any such circumstances, it is suggested that you instantaneously call the Help Line or request urgent emergency health attention. You might have indications like vomiting, anxiety, hasty heart rate, and lack of sensation or stinging feeling.

What Are The Things To Avoid When Using Pristiq?

Consuming alcohol might raise certain Pristiq side effects. Pristiq might impair your thoughts or responses. Be cautious if you’re driving or doing anything that calls for you to be attentive. Keep away from tanning beds and contact with sunshine. Pristiq might make you susceptible to sunburns. Be dressed in defensive clothing and apply sunscreen (at least SPF 15 if not higher) while you’re out-of-doors.

Pristiq Side Effects for the User:

Just like any other medicine, the side effects are likely with Pristiq too. Nevertheless, not everybody who uses this drug will face problems. Actually, the majority of people stomach it rather well. If Pristiq side effects crop up, in nearly all cases, they’re inconsequential and either necessitate no cure or else can be simply treated by your healthcare provider or you.

  • Decrease in sexual ability or desire;
  • Constipation;
  • Faintness;
  • Diarrhea;
  • Dryness in mouth;
  • Drowsiness;
  • Reddening of skin;
  • Fatigue;
  • Amplified sweating;
  • Headache;
  • Nausea;
  • Loss in desire for food;
  • Difficulty sleeping;
  • Stomach upset;
  • Yawning;
  • Vomiting.

It’s suggested that you demand medicinal attention without ado if any RELENTLESS Pristiq side effect occurs when consuming Pristiq:

Severe allergic reaction like:


  • Hives;
  • Skin complaint;
  • Trouble in inhalation;
  • Itchiness;
  • Distension of the mouth, tongue, face, lips,;
  • Tension in the upper body;
  • Actions changes;
  • Abnormal hoarseness;
  • Vague vision;
  • Bloody stools;
  • Confusion;
  • Chest twinge or soreness;
  • Decrease in synchronization;
  • Decrease in attentiveness;
  • Distended pupils;
  • Decrease in urination;
  • Swift or unbalanced heartbeat;
  • Feeling weak;
  • Hallucinations;
  • Sore throat, Fever, or chills;
  • Fresh or aggravated agitation, nervousness, panic attacks, violence, impulsiveness, bad temper, hostility, agitation, or lack of ability to sit motionless;
  • Recall problems;
  • Red, puffed-up, blistered, or flaking skin;
  • Fresh or aggravated psychological or temper changes;
  • Harsh or continual cough;
  • Seizures;
  • Harsh or continual problem sleeping;
  • Harsh or continual headaches, giddiness, or stomach ache;
  • Noteworthy weight loss;
  • Shortness in breathing;
  • Quivering;
  • Feelings or attempt to Suicide;
  • Deterioration of depression;
  • Remarkable weakness;
  • Odd bruising or blood loss.


What Are The Other Drugs That Will Have An Effect On Pristiq?

Inquire your health care practitioner ahead of taking any medication for arthritis, fever, pain, or inflammation. This takes account of ibuprofen (Motrin, Advil), aspirin, celecoxib (Celebrex), naproxen (Aleve, Treximet, Naprosyn, Naprelan), meloxicam (Mobic), and indomethacin (Indocin), etc. Using any of the mentioned medications along with Pristiq might cause easy blood loss or bruising.


Before taking Pristiq, notify your health care practitioner in case you frequently use additional medicines that might make you drowsy (for instance allergy or cold medication, narcotic pain drug, sedatives, sleeping medication, muscle relaxant, and medicines for convulsion or nervousness). They can stimulate sleepiness which is caused by this drug.


Inform or notify your health care practioner on the subject of all additional medications that you are taking, in particular:


  • Any diuretic (or water pills);
  • Any blood thinners for instance warfarin (or Coumadin);
  • Lithium (Lithobid , Eskalith);
  • Linezolid (Zyvox);
  • Tryptophan (from time to time identified as L-tryptophan);
  • Midazolam (Versed);
  • Metoclopramide (Reglan);
  • Tramadol (Ultram, Ryzolt, Ultracet, Rybix, Synapryn);
  • St. John’s wort;
  • Antifungal medications for instance itraconazole (Sporanox), clotrimazole (or Mycelex Troche), voriconazole (Vfend) or ketoconazole (Extina, Xolegal, Ketozole, Nizoral);
  • Blood pressure or heart medications for instance diltiazem (Cardizem , Cartia), nifedipine (Procardia , Nifedical), verapamil (Covera, Isoptin, Calan, Verelan), and others;
  • Any antibiotic for instance erythromycin (Ery-Tab, E.E.S., eryped, Erythrocin), clarithromycin (Biaxin), telithromycin (Ketek), etc;
  • Any migraine headache prescription for instance almotriptan (Axert), sumatriptan (Treximet ,Imitrex), naratriptan (Amerge), frovatriptan (Frova), zolmitriptan (Zomig) or rizatriptan (Maxalt);
  • Any HIV/AIDS medication for instance indinavir (Crixivan), fosamprenavir (Lexiva), ritonavir (Norvir), etc;
  • Any additional antidepressant for instance citalopram (Celexa), amitriptyline (Vanatrip ,Elavil), escitalopram (Lexapro), fluoxetine (Sarafem, Symbyax ,Prozac), duloxetine (Cymbalta), sertraline (Zoloft), or paroxetine (Pexeva , Paxil).


Drug Interactions for Pristiq (Desvenlafaxine):

A sum total of 913 medications (5454 brand and generic names) generic and brand names) are recognized to act together with Pristiq (Desvenlafaxine).


  • 197 main medicine interactions
  • 713 temperate medicine interactions
  • 3 insignificant medicine interactions


General medications verified in association with Pristiq (Desvenlafaxine):


  • Adderall (dextroamphetamine /amphetamine)
  • Abilify (aripiprazole)
  • Clonazepam
  • Ambien (zolpidem)
  • Klonopin (clonazepam)
  • Gabapentin
  • Lisinopril
  • Levothyroxine
  • Lyrica (pregabalin)
  • Lorazepam
  • Nexium (esomeprazole)
  • Metformin
  • Simvastatin
  • Omeprazole
  • Synthroid (levothyroxine)
  • Singulair (montelukast)
  • Tramadol
  • Topamax (topiramate)
  • Xanax (alprazolam)
  • Trazodone