Glyburide Side Effects – Dosage, Interaction & Vital Information

Glyburide Side Effects for the User:

Medicines and drugs may lead to some side effects, but lots of people have no side effects, or slight side effects. Confirm with the doctor if a few of these COMMON side effects endure or turn out to be bothersome while using Glyburide:

  • Mild nausea, feeling full or heartburn,;
  • Muscle or joint twinge;
  • Fuzzy vision;
  • Mild skin rashes or itchiness;
  • Gain in weight

It is recommended that you request medical attention without ado if any SEVERE Glyburide side effect occurs when with Glyburide:

  • Severe allergic reaction like:


Complicatedness in breathing;

Inflammation in your lips, tongue, face or throat.


  • Unsettled stomach,
  • Stomach ache,
  • Low fever,
  • Dark urine,
  • Loss in appetite,
  •  Jaundice (yellowing in eyes and skin);
  • Clay-color stools,
  • Paleness of skin,
  •  Perplexity or weakness;
  • Easy blood loss or bruising,
  •  Red or  purple pinpoint spots underneath your skin; or
  • Headaches,
  • Difficulty concentrating,
  •  Recall problems,
  •  Feeling wobbly,
  • Hallucinations,
  • Sensation that you might lose consciousness,
  • Spasms,
  • Petty breathing that stops.

Bear in mind that your health care practioner has approved this prescription for the reason that he/she has felt that the benefits involved in using this drug will be superior to the risks involved when you would consume this medicine.

This medicine can source stumpy blood sugar (or hypoglycemia). This outcome might happen if you don’t consume adequate calories (from juices, fruit, food, etc.). The signs consist of:

  • Chills,
  • Vague vision,
  • Cold sweat,
  • Lightheadedness,
  • Drowsiness,
  • Trembling,
  • Hasty heart rate,
  • Headaches,
  • Weakness,
  • Stinging of the feet and hands,
  • Fainting,
  • Feeling hungry.

It’s an excellent routine to carry a glucose gel or tablets to treat stumpy blood sugar. In case you’re in a condition where there is no reliable form of glucose, quickly eat a sugar source for instance table sugar, candy, honey, or sip a glass of milk, non- diet soda or orange juice to rapidly lift your level of blood sugar. Inform your health care practioner at once concerning the reaction. To facilitate prevention of hypoglycemia, remember to eat meals at regular periods and don’t leave out meals. Signs of lofty blood sugar (or hyperglycemia) consist of thirst, greater than before urination, perplexity, sleepiness, flushing, hasty breathing, or fruity odor in breath.

Inform your health care practioner at once if any of these signs crop up. Your medication dose might call for an increase. An allergy to this medicine is improbable, but you must seek immediate health attention in case it occurs. Signs of an allergy comprise: rashes, itchiness/puffiness (in particular of the tongue/throat/face), dizziness, difficulty breathing.

This isn’t the entire list of Glyburide side effects which a person might be prone to. If you’ve got any queries about Glyburide side effects, get in touch with your doctor or pharmacist. Call your healthcare provider for medical counseling regarding side effects of Glyburide.


Glyburide’s an anti-diabetic medicine (sulfonylurea-type) made use of together with a suitable diet plan and work out program to manage lofty blood sugar level. Glyburide is made use of in people who go through from type 2 diabetes (also identified as non-insulin-reliant diabetes). Glyburide works by invigorating the discharge of natural insulin inside your body. Keeping elevated blood sugar level in control helps thwart kidney injury, nerve problems, blindness; sexual function troubles or loss of a limb. Appropriate management of diabetes might also reduce your risks of a stroke or heart attack.


How to Use Glyburide:

Consume Glyburide precisely as approved for you by your health care practioner. Don’t use in bigger or lesser amounts or even for longer duration than what has been recommended to you by your health care practioner. Follow the instructions on your treatment label.

The health care practioner might alter your prescribed amount, every now and then, to be sure you that you are getting the finest results.

Use this medicine through your mouth along with breakfast or may be with the initial main meal that you eat, usually once on a daily basis; or take as advised by your health care practioner. Some people, in particular those using higher dosage, might be advised to use this medicine twice daily. The dose is based upon your health condition and reaction to therapy. Take this drug on a regular basis so as to get the maximum benefits from the treatment. To aid you remember, take it at similar time(s) every day. Observe your blood glucose level on a standard basis. Notify your health care practioner in case your blood glucose level is too elevated or too stumpy.

Blood sugar level will need regular checking, and you might need additional blood examinations at your health care provider’s office. Stop over your health care practioner on a regular basis.

Identify the indications of stumpy blood sugar (or hypoglycemia) and ways to identify them: headaches, hunger, tremor, weakness, sweating, bad temper, or problem concentrating.

At all times maintain a supply of sugar on hand in case there are signs of stumpy blood sugar. Some sugar sources consist of glucose gel, orange juice, milk or candy. In case you have relentless hypoglycemia and you’re unable to drink or eat, get a shot of glucagon. The health care practioner can offer you a treatment for glucagon crisis injection supplies and update you on how to administer the shot.

Furthermore, watch for indications of blood sugar which are too lofty (hyperglycemia). These signs include amplified thirst, greater than before urination, hunger, dryness of mouth, fruity odor in breath, drowsiness, blurred vision, dry skin, and loss in weight.

Test your blood sugar level vigilantly for the period of constant worry or poor health, in case you travel, work out more than accustomed, consume alcohol, or leave out meals in the day. Such things are capable of affecting the glucose level in your body and your prescribed amount requirement might also change.

The health care practioner might wish for you to discontinue using Glyburide for a while in case you turn out to be in poor health, catch an infection or are running a fever, or in case you have to undergo a surgical procedure or have a health crisis.

If there is any change in the strength, brand, or variety of Glyburide you take, your dose needs might vary. Always ensure your restock to be sure that you have obtained the right brand and variety of medication agreed by your health care practioner.

Store Glyburide protected from light, moisture and heat, and keep at room temperatures.


Vital Information In Relation To Glyburide:

You must not take this drug if you’re sensitive to Glyburide, in case you’re undergoing treatment using bosentan (Tracleer), in case you suffer from type 1 (also known as insulin-reliant) diabetes, or in case you’re in a situation called as diabetic ketoacidosis (In such circumstances, it is highly recommended that you immediately get in touch with your health care practioner and request treatment using insulin).

Before using Glyburide, inform your health care practioner if you’re sensitive to sulfa drugs, in case you use chlorpropamide (Diabinese) or insulin or in case you go through hemolytic anemia (which is a deficit of RBCs), an enzyme deficit (G6PD), nerve disorders, liver ailment, or kidney ailment.

Be careful not to allow your level of blood sugar to fall too low. A stumpy blood sugar (also identified as hypoglycemia) might crop up if you leave out a meal, work out too long, consume alcohol, or in case you’re under constant worry. Symptoms consist of headaches, weakness, sweating, hunger, tremors, bad temper, or difficulty concentrating. Keep at hand glucose tablets or hard candy in case your blood sugar level dips. Additional sugar resources consist of milk and orange juice. Be definite your close friends and family be familiar with how they can assist you in case of an urgent situation.


Ahead Of Using Glyburide:

Certain oral medication for diabetes might increase your risks of grave heart problems. Nevertheless, not getting treated for diabetes can be damaging for your organs as well as heart. Speak to your health care practioner regarding the risk and benefit of treating diabetes along with Glyburide.

It’s not acknowledged whether Glyburide can cause harm to an unborn child. Related diabetes medication has caused harsh hypoglycemia in the case of newborn children where mothers had taken the medicine close to their occasion of delivery. Inform your health care practioner if you’re pregnant or are planning a pregnancy while taking Glyburide. It’s not acknowledged whether Glyburide is capable of passing into a nursing mother’s breast milk or if it’s capable of harming a nursing newborn. Don’t use this drug without notifying your health care practioner if you’re breast-feeding your baby. Elder adults might be more prone to stumpy blood sugar levels while using Glyburide.


What Will Happen If You Fail To Spot And Leave Out A Dosage?

Consume the dose (that you have missed out on) the moment you remember. (Make sure to use the medication along with food in case your health care practioner has directed you to do so). Leave out the dose that you have missed o if out on if it’s roughly time for the next planned prescribed amount. Don’t use extra medication to make up for the dose that you earlier missed out on.


What Will Happen If You Consume An Overdose Of Glyburide?

Under such a situation, it is recommended that you immediately call the Help Line or seek immediate emergency health attention. You might have indications of harsh hypoglycemia which take account of intense weakness, distorted vision, difficulty speaking, sweating, trembling, stomach soreness, puzzlement, and seizures (convulsions).


What Are The Things To Avoid When Using Glyburide?

Steer clear of consuming alcohol. It worsens stumpy blood sugar level and might meddle with your treatment for diabetes. Avoid contact with tanning beds or sunlight. Glyburide can cause sunburns more easily. Put on protective clothing as well as use sunscreen (at least SPF 30 or even higher) when you’re outdoors.


What Are The Other Drugs That Will Have An Effect On Glyburide?


Inform or notify your health care practioner on the subject of all additional medications that you are taking, in particular:


  • Cyclosporine (Neoral, Sandimmune, Gengraf);
  • Any blood thinner for instance warfarin (Coumadin);
  • Ketoconazole (Nizoral),  fluconazole (Diflucan);
  • Disopyramide (Norpace);
  • Rifampin (Rimactane, Rifater, Rifadin);
  • Fluoxetine (Prozac);
  • Any ACE inhibitor for example ramipril (Altace),  lisinopril (Zestril, Prinivil), enalapril (Vasotec), and others; or
  • Any antibiotic for instance levofloxacin (Levaquin), ciprofloxacin (Cipro), and others.


Taking a few medicines can make it tougher to notify when you come across stumpy blood sugar. Inform your health care practioner if you take any of the subsequent:


  • Clonidine (catapres);
  • Albuterol (ventolin, proventil);
  • Guanethidine (ismelin);
  • Reserpine;
  • Any beta-blockers for example carvedilol (coreg), atenolol (tenormin), propranolol (innopran , inderal),  metoprolol (toprol, lopressor), and others.


One might be more prone to face hyperglycemia (lofty blood sugar) in case he/she takes Glyburide with:

  • Steroids (prednisone, etc);
  • Isoniazid;
  • Phenothiazines (Compazine, etc);
  • Diuretics (also known as water pills);
  • Thyroid medicines (Synthroid, etc);
  • Pills for  birth control ;
  • Blood pressure or heart medication (Cartia, Covera, Verelan, Cardizem, Nifedical,  and others);
  • Pills for other hormones;
  • Niacin (Advicor, Simcor, Niaspan, Niacor, Slo-Niacin, and others);
  • Seizure medicine (Dilantin, etc); and
  • Diet pill or medicine to take care of asthma, allergies or cold.


One might be more prone to face hypoglycemia (stumpy blood sugar) in case he/she takes Glyburide with:


  • Probenecid (Benemid);
  • Exenatide (Byetta);
  • Clarithromycin (Biaxin);
  • Aspirin or any other salicylates (like Pepto-Bismol);
  • Blood pressure or heart medication (Zestril, Accupril, Prinivil, Vasotec, Altace, Lotensin, and others);
  • Sulfa drugs (Septra, Bactrim, Gantanol,  and others);
  • Any NSAIDs (nonsteroidal anti-inflammatory drugs);
  • Other oral medications for diabetes, in particular metformin (Glucophage), acarbose (Precose), miglitol (Glyset), rosiglitazone (Avandia) or pioglitazone (Actos);
  • Any monoamine oxidase inhibitors (MAOIs).

There might be more medicines that are capable of increasing or decreasing the effect of Glyburide on worsening stumpy blood sugar. This list isn’t inclusive and there might be other medicines that may act together with Glyburide. Inform your health care provider about every prescription and/or non prescription drugs, vitamins, herbal products, minerals, and medicines prescribed by some other doctor. Do not begin a new prescription without consulting your health care provider.