Fluoxetine Side Effects | Uses, Interactions


Side Effects of Fluoxetine:

  • Fretfulness;
  • Decrease in sexual ability or desire;
  • Diarrhea;
  • Giddiness;
  • Drowsiness;
  • Dryness of mouth;
  • Symptoms of flu (e.g., chills, fever, muscle aches);
  • Excessive sweating;
  • Nausea;
  • Loss in appetite;
  • Anxiety;
  • Runny nose;
  • Soreness in throat;
  • Upset stomach;
  • Difficulty sleeping;
  • Weakness.


Severe allergic reaction like:

  • Rashes;
  • Hives;
  • Itch;
  • Trouble breathing;
  • Tension in chest;
  • Inflammation of the lips, face, mouth, or tongue;
  • Strange hoarseness;
  • Out of the ordinary behavior;
  • Bloody or black stools;
  • Confusion;
  • Chest soreness;
  • Decrease in concentration;
  • Decrease in coordination;
  • Exaggerated reflexes;
  • Extreme sweating;
  • Fainting;
  • Hasty or unbalanced heartbeat;
  • Chills, fever, or sore throat;
  • Increased thirst, hunger, or urination;
  • Memory loss;
  • Hallucinations;
  • Wrist or joint ache or pain;
  • Aggravated or new anxiety, fright attacks, hostility, impulsiveness, irritability, aggression, exaggerated sensitivity of restlessness, well-being, or incapability to sit motionless;
  • Unrelenting or harsh ringing in ears;
  • Unrelenting, painful erection;
  • Swollen, red, scalded, or flaking skin;
  • Spasms;
  • Unrelenting or harsh anxiety, weakness, difficulty sleeping;
  • Unrelenting or harsh nausea, sickness, diarrhea, or headaches;
  • Significant loss in weight;
  • Stomach ache;
  • Suicidal feelings or attempts;
  • Trouble urinating;
  • Tremor;
  • Strange bleeding or bruising;
  • Strange hoarseness;
  • Strange or harsh psychological or temper changes;
  • Strange swelling;
  • Strange weakness;
  • Changes in vision;
  • Greater depression.

Drug Class and Mechanism:

An oral drug, Fluoxetine is made use of for management and handling depression. It belongs to a category of medication known as selective serotonin reuptake inhibitors (SSRIs), which is a category of drugs which also include paroxetine (Paxil), citalopram (Celexa), and sertraline (Zoloft). The drug influences neurotransmitters, the chemical which are made use of by the nerves inside the brain to correspond with one another. Neurotransmitters are produced and released by the nerves and subsequently travel and affix to close by nerves. As a consequence, neurotransmitters may be considered as the communiqué system for the brain. One of the neurotransmitters that the nerve inside the brain releases is Serotonin. Serotonin either moves across the gap connecting the nerves and then fastens to receptors at the exterior of close by nerves or attaches to receptors at the exterior of the nerves that produce it, in order to be made use of by the nerves in addition to being released once more (a practice known as re-uptake).

Several experts consider that a disproportion amongst neurotransmitters is the reason for depression. Fluoxetine functions by avoiding the re-uptake of a single neurotransmitter, the serotonin, through nerve cells subsequent to it being released. Because uptake is a significant mechanism for eliminating released neurotransmitters and ceasing their proceedings on adjoining nerves, the condensed uptake attributable to Fluoxetine raises free serotonin which fuels nerve cells within the brain. In December 1987, Fluoxetine was approved by the FDA.


Prescribed For:

Fluoxetine is made use of for management and handling of bulimia, depression, premenstrual dysphoric disorder (PMDD), obsessive-compulsive disorder (OCD), and panic disorder. It’s furthermore made use of in permutation with olanzapine (Zyprexa) to treat defiant depression along with treatment for depression linked with bipolar disorders.




Despair in adults is handled by 20-80 mg, on a daily basis, of Fluoxetine. The suggested prescribed amount for management and handling of depression in kids is 10-20 mg on a daily basis. Subsequent to 13 weeks of every day administration, a onetime weekly dose may be useful in a few people.

Bulimia is handled by means of 60 mg, on a daily basis, of Fluoxetine. Long-term treatments for about 52 weeks have revealed to be advantageous in maintaining remissions.

Obsessive-compulsive disorder or OCD in children and adults is handled by means of 20-60 mg, on a daily basis, and panic disarray is handled by means of 10-60 mg, on a daily basis. The suggested PMDD routine is 20 mg which is given daily during menstrual phase or every day used for 14 days before the commencement of the menstruation all the way through the initial date of menses.



About Fluoxetine:

This drug is an SSRI (selective serotonin reuptake inhibitors) antidepressant. Fluoxetine influences chemicals within the brain which might turn out to be disturbed and source depression, anxiety, fright, or OCD (obsessive-compulsive disorder) symptoms.

Fluoxetine is made use of to handle major depressive disorders, obsessive-compulsive disorders, bulimia nervosa (i.e. an eating disorder), premenstrual dysphoric disorder (PMDD) and panic disorders.

Fluoxetine is occasionally made use of collectively with an additional medication known as olanzapine (Zyprexa) to take care of depression sourced by a bipolar disorder or manic depression. This mixture is also made use of to take care of depression after as a minimum 2 additional medications have been used without thriving treatment of indications.



Vital Information Regarding Fluoxetine:

Don’t take Fluoxetine alongside thioridazine (Mellaril), pimozide (Orap), or any MAO inhibitors for instance tranylcypromine (Parnate) , furazolidone (Furoxone), phenelzine (Nardil), isocarboxazid (Marplan), selegiline (Emsam, Eldepryl, Zelapar) or rasagiline (Azilect),


. A risky drug contact could come about, resulting in grave Fluoxetine side effects.

One might have feelings about suicide once he/she first begins to use an antidepressant, particularly in case he/she is less to 24 years in age. Your physician will have to test you at normal visits for as a minimum the initial 12 weeks in your treatment using Fluoxetine.

Account any aggravated or new symptoms to your physician, for example:

  • Behavior or Mood alterations,
  • Anxiety,
  • Difficulty sleeping,
  • Feeling impulsive,
  • Feeling irritable,
  • Feeling agitated,
  • Panic attacks,
  • Feeling hostile,
  • Feeling aggressive,
  • Feeling restless,
  • Feeling hyperactive (psychologically or physically),
  • Feeling more depressed,
  • Have feelings about hurting yourself or suicide


Fluoxetine might cause grave lung troubles in an infant in case you use the medication for the duration of pregnancy. Nevertheless, you might face a relapse in depression in case you discontinue using your antidepressant at some stage in pregnancy. In case you turn out to be pregnant when using Fluoxetine, don’t discontinue taking the medicine without talking first to your doctor.



Prior To Using Fluoxetine:

Don’t use Fluoxetine in case you’re taking any of the subsequent drugs:

  • Thioridazine (Mellaril);
  • Pimozide (Orap);
  • Any MAO inhibitors like isocarboxazid (Marplan), furazolidone (Furoxone), rasagiline (Azilect), phenelzine (Nardil), tranylcypromine (Parnate) or selegiline (Emsam, Eldepryl, Zelapar)


Severe and sometimes deadly reactions may come about when these drugs are used along with Fluoxetine. You should wait for a minimum of 14 days (prior to taking Fluoxetine) once you have stopped using your MAO inhibitor. One should wait for 5 weeks (once he/she has discontinued Fluoxetine) before he/she can use an MAOI.

In order to be sure if you can securely use Fluoxetine, inform your doctor in case you face any of the below mentioned conditions:


  • Kidney ailment;
  • Liver cirrhosis;
  • Spasms or epilepsy;
  • Diabetes;
  • A record of suicidal thoughts or drug abuse
  • Bipolar disarray or manic depression


You might have feelings regarding suicide while using an antidepressant, particularly if you’re lesser to 24 years in age. Inform your doctor in case you have aggravated dejection or suicidal feelings during the initial few weeks with Fluoxetine or each time your prescribed amount is altered.

A patient’s family or further caregivers must also be vigilant to change in the patient’s symptoms or mood. Your health care provider will require testing you at normal visits for as a minimum the initial 12 weeks in Fluoxetine treatment.

Fluoxetine is capable of passing into a nursing mother’s breast milk and might hurt a nursing newborn. Don’t take this drug without informing your health care provider in case you’re breast-feeding a newborn. Don’t offer Fluoxetine to anybody lesser than 18 years in age without a health care provider’s advice.



Drug Interactions of Fluoxetine:

It shouldn’t be used along with any MAOI (monoamine oxidase inhibitor) category of antidepressants for instance, procarbazine (Matulane), phenelzine (Nardil), isocarboxazid (Marplan), selegiline (Eldepryl), tranylcypromine (Parnate)] or extra medication that restrains monoamine oxidase [for instance, linezolid (Zyvox)].

Similar combinations might lead to perplexity, death, elevated blood pressure, hyperactivity, tremor, and coma. Fluoxetine shouldn’t be taken for as a minimum of 14 days once you have stopped using MAOIs. Since Fluoxetine is dynamic within the body for numerous weeks, the MAOIs shouldn’t be taken for as a minimum of 5 weeks once Fluoxetine has been discontinued. Related reactions come about if Fluoxetine is pooled with further medication, for instance, St. John’s wort, tryptophan, tramadol (Ultram) and meperidine (Demerol), and which increases serotonin within the brain.



How to Use Fluoxetine:

Use Fluoxetine precisely as approved by your health care provider. Don’t use in bigger or lesser amounts or even for longer durations than suggested. Follow the instructions on your direction label.

Your health care provider might rarely alter your prescribed amount of Fluoxetine to be sure you are getting the paramount results.

Don’t chew, crush, open or break a Fluoxetine extended-release capsule. Gulp down whole. Opening or breaking the capsule might cause a lot of the medicine to be freed at once.


Evaluate liquid medication with a particular dosage medicine cup or measuring spoon, not through a normal table spoon. In case you don’t have a dosage measuring tool, request the pharmacist for the same.

It might take about 4 weeks and even longer before one start to feel better. Don’t discontinue taking Fluoxetine without talking first to your health care provider. You might have disagreeable side effects of Fluoxetine if you discontinue taking this drug suddenly.

To handle premenstrual dysphoric disorders, the standard dosage of Fluoxetine is one time on a daily basis when you’re having periods, or 14 days prior to you expecting your periods to begin. Follow your health care provider’s instructions.

Stock up Fluoxetine away from heat and moisture and at room temperatures.